Nasal drug delivery has been widely used as an alternative route for the systemic delivery of drugs. This is due to the large surface area, high total blood flow, the avoidance of first-pass metabolism, and ease of application. In recent years the nasal administration of drugs, include various peptide and protein drugs, These drug delivery systems have the ability to control the rate of drug clearance ,In addition, absorption of drug at the olfactory region of the nose provides a potential for a pharmaceutical compound to be available to the central nervous system. The nasal mucosa is an attractive area to deliver medications because the procedure is painless and needleless, which eliminates the risk of needle-stick injuries and reduces patient discomfort. Drug delivery through the nasal route has been used for the treatment of local diseases such as nasal congestion, allergies, infections and CNS disorder. The purpose of this review is to provide an overview of the anatomical and physiological considerations of the nose, mechanism of nasal drug absorption, drug metabolism and. factors that will affect formulation development and design of nasal products. Now the world market has seen an increasing number of systemically acting drugs being marketed as nasal formulations.
Loading....